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sudo chkconfig iptables on
sudo service iptables save

Debian/Ubuntu:

Install iptables-persistent package and the netfilter-persistent  packages:

sudo apt-get install iptables-persistent
sudo apt-get install netfilter-persistent

To save current iptable rules to these files, run the following:

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sudo iptables-restore < /etc/iptables/rules.v4
sudo ip6tables-restore < /etc/iptables/rules.v6

The netfilter-persistent  package has the actual init.d service which reloads the last saved iptables configuration.  So, once saved (see above) start and enable the service by:

sudo systemctl start netfilter-persistent
sudo systemctl enable netfilter-persistent

References

1. https://help.ubuntu.com/community/IptablesHowTo
2. https://www.thomas-krenn.com/en/wiki/Saving_Iptables_Firewall_Rules_Permanently

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